Collective Dynamics and Mechanics

Collective cell motion is involved in various biological processes, from the generation of curved epithelia to cancer invasion and metastasis. In our lab, we are interested in collective cell behaviours and their mechanical properties. We study how force generation and transmission can shape 2D and 3D cell arrangements. In particular, we focus on the molecular cues driving cell-cell and cell-substrate interactions.

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We study the effect of tissue fluidification on collective migration of cancer spheroids, from 2D to more 3D-like environments. This interdisciplinary research topic lies at the interface between cellular biology, physico-chemistry, microfabrication and microscopy. For example, using microfluidics, we try to understand how confinement and mechanical stress can tune the invasion of cell collectives.
Grégoire Lemahieu

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Epithelial monolayers occur in organisms in all forms, from spherical in alveoli to tubular in the kidney. This project investigates the biophysical mechanisms involved in the formation and rigidity of such 3D epithelial cell collectives at the molecular level. Thereby, focusing on cell-cell adhesion and the force generation and transmission across cells. With these investigations, we want to shed light on how adherent junctions contribute to the stability of curved epithelial monolayers.

For more information on this project get in contact with Michelle Kemper.

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